<p><b>A</b>. BV173 or BV173R cells were treated with imatinib mesylate (5 µM) for 12 hours. RNA was extracted and expression of SESN3 mRNA was determined by quantitative RT-PCR, using GAPDH for normalization. Data are expressed as fold increase in the treated samples over untreated samples and represent means ± S.E. of 3 independent experiments. <b>B</b>. BV173 or BV173R cells were treated with either imatinib (5 µM) or nilotinib (100 nM) for 16 hours. Total cell lysates were resolved by SDS-PAGE and immunoblotted with antibodies against SESN3 or GAPDH as indicated. <b>C</b>. Ba/F3 cells stably transfected with WT-BCR-ABL or T315I-BCR-ABL were treated with either imatinib (1 µM) or nilotinib (100 nM) for 16 hours. Total cell lysates were re...
<p>Z119 cells were treated with indicated doses canertinib or lapatinib and (A) imatinib, (B) niloti...
<p>(<b>A</b>) 435s/M14 cells, transfected with STAT3 siRNA, were drug treated (8 h), and nuclear fra...
<p>(A) BaF3-BCR/ABL<sup>T315I</sup>, BaF3-BCR/ABL<sup>T315I</sup> -NC and BaF3-BCR/ABL<sup>T315I</su...
<p><b>A</b>. Ba/F3 cells stably transfected with T315I-BCR-ABL were treated with ponatinib (10 nM) o...
Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized by the p...
<div><p>Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized ...
Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized by the p...
<p><b>A</b>. KT-1 cells were transiently nucleofected with either empty vector (E.V.) or SESN3 expre...
<p><b>A</b>. KT-1 cells were transiently nucleofected with either empty vector (E.V.) or a SESN3 exp...
<p>(<b>A</b>) 32Dp210 cells were cultured for 24 h with 0.5 µM etoposide (Etop.), 0.6 µM imatinib, o...
Objective To analyze the influence of SH3 domain mutant (ABL SH3-T79Y) in BCR-ABL protein of chronic...
OBJECTIVE This study investigated two approaches, short hairpin RNA (shRNA) and the potent ABL in...
<p>BCR-ABL+ (BV, PH, KW, CM, BV und DW), TEL-ABL+ (VG) and BCR-ABL- (HP, KR, RL, CR und SK) LTCs wer...
<p>(<b>A</b>): The activity of tyrosine kinases in the neutrophils. Neutrophils were incubated with ...
Glutathione peroxidase activity was previously determined to be elevated in lymphocytes obtained fro...
<p>Z119 cells were treated with indicated doses canertinib or lapatinib and (A) imatinib, (B) niloti...
<p>(<b>A</b>) 435s/M14 cells, transfected with STAT3 siRNA, were drug treated (8 h), and nuclear fra...
<p>(A) BaF3-BCR/ABL<sup>T315I</sup>, BaF3-BCR/ABL<sup>T315I</sup> -NC and BaF3-BCR/ABL<sup>T315I</su...
<p><b>A</b>. Ba/F3 cells stably transfected with T315I-BCR-ABL were treated with ponatinib (10 nM) o...
Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized by the p...
<div><p>Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized ...
Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized by the p...
<p><b>A</b>. KT-1 cells were transiently nucleofected with either empty vector (E.V.) or SESN3 expre...
<p><b>A</b>. KT-1 cells were transiently nucleofected with either empty vector (E.V.) or a SESN3 exp...
<p>(<b>A</b>) 32Dp210 cells were cultured for 24 h with 0.5 µM etoposide (Etop.), 0.6 µM imatinib, o...
Objective To analyze the influence of SH3 domain mutant (ABL SH3-T79Y) in BCR-ABL protein of chronic...
OBJECTIVE This study investigated two approaches, short hairpin RNA (shRNA) and the potent ABL in...
<p>BCR-ABL+ (BV, PH, KW, CM, BV und DW), TEL-ABL+ (VG) and BCR-ABL- (HP, KR, RL, CR und SK) LTCs wer...
<p>(<b>A</b>): The activity of tyrosine kinases in the neutrophils. Neutrophils were incubated with ...
Glutathione peroxidase activity was previously determined to be elevated in lymphocytes obtained fro...
<p>Z119 cells were treated with indicated doses canertinib or lapatinib and (A) imatinib, (B) niloti...
<p>(<b>A</b>) 435s/M14 cells, transfected with STAT3 siRNA, were drug treated (8 h), and nuclear fra...
<p>(A) BaF3-BCR/ABL<sup>T315I</sup>, BaF3-BCR/ABL<sup>T315I</sup> -NC and BaF3-BCR/ABL<sup>T315I</su...