Differentially expressed genes associated with five top canonical pathways derived from IPA analysis.

<p><b>Genes </b><b>are </b><b>categorized </b><b>into </b><b>four </b><b>major </b><b>functions</b> (cell cycle regulation-orange, xenobiotic metabolism-green, inflammation-violet, and tissue fibrosis-blue). All genes in both models are regulated by a common transcription factor, AHR. Genes highlighted with green indicate down-regulation and genes highlighted with red indicate up-regulation. The transcription factor AHR is down-regulated in cells, suggesting negative regulation of the downstream functions in cells.