Performance on the rotarod test.

<div><p>The rotarod test was performed to evaluate motor coordination and motor learning on Days 8, 9, 12, and 15 after the initiation of CIH or NOX treatments. On the second day of rotarod testing (Day 9), the Wt and ALS-NOX mice showed marked improvement in rotarod retention times, compared to their performance on the first day of testing (Day 8). In contrast, compared with the ALS-NOX mice, the ALS-CIH mice did not show an improvement in rotarod retention times and had significantly shorter rotarod retention times on Day 9 (<i>p</i> < 0.05), which could be the results of impairment in motor learning ability. In addition, ALS-CIH mice tended to show shorter rotarod retention times than the ALS-NOX mice did throughout the serial follow-up period, although this trend did not reach statistical significance for Days 8, 12, or 15. </p> <p>* <i>p</i> < 0.05, **, <i>p</i> < 0.01.</p>