<p>Number of γ-H2AX foci after exposure to 0.1 Gy at time 0 plus 1 Gy delivered 1 hr after (left column) and 4 hr later (right column). Top panels report the experimental data;bottom panels, data are fitted using the modelling <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079541#eqn4" target="_blank">equation (4)</a>. In the bottom panels, the solid line represents the modelling function for the split dose scenario. The dotted lines represent the modelling function for the individual radiation exposures. Error bars represent the standard error of the mean of 3 independent experiments. </p
(A) Representative immunofluorescence images of 387 GSCs harvested at 30 min, 24 hrs and 48 hours af...
Simulation of different experimental protocols consisting of spacing each single dose by a given num...
<p>(a) illustrates the dose effect curve. Samples were irradiated with doses ranging from 5 to 50 mG...
<p>Number of γ-H2AX foci per cell after exposure to 1 Gy at time 0 plus 1 Gy delivered20 min later (...
<p>Comparison of clonogenic survival following acute (2 Gy) and split dose (1 Gy + 1 Gy) exposures w...
<p>(A) γ-H2AX foci distribution at 24 hours after exposure of 100% of the cells to 0.5 Gy or 10% of ...
<p>Panel A: experimental data of flow cytometry measurements after irradiation with different X-rays...
<p>The lines in this figure represent a fit of the GLOBLE to survival curves of the MT cell line. Th...
<p>Here, parameters derived with fits of the GLOBLE to dose rate or split dose experiments in 17 cel...
<p>Estimated number of γ-H2AX foci induced by the second irradiation only as calculated by subtracti...
<p>(A) Box-and-whisker plot of the number of gamma H2AX foci per nucleus for each tested dose and th...
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast m...
<p>This figure shows the survival probability of a LL cell line measured in a split dose experiment ...
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast m...
<p>(A) γ-H2AX intensity histograms for different irradiated fractions at 1 hour post exposure. (B) E...
(A) Representative immunofluorescence images of 387 GSCs harvested at 30 min, 24 hrs and 48 hours af...
Simulation of different experimental protocols consisting of spacing each single dose by a given num...
<p>(a) illustrates the dose effect curve. Samples were irradiated with doses ranging from 5 to 50 mG...
<p>Number of γ-H2AX foci per cell after exposure to 1 Gy at time 0 plus 1 Gy delivered20 min later (...
<p>Comparison of clonogenic survival following acute (2 Gy) and split dose (1 Gy + 1 Gy) exposures w...
<p>(A) γ-H2AX foci distribution at 24 hours after exposure of 100% of the cells to 0.5 Gy or 10% of ...
<p>Panel A: experimental data of flow cytometry measurements after irradiation with different X-rays...
<p>The lines in this figure represent a fit of the GLOBLE to survival curves of the MT cell line. Th...
<p>Here, parameters derived with fits of the GLOBLE to dose rate or split dose experiments in 17 cel...
<p>Estimated number of γ-H2AX foci induced by the second irradiation only as calculated by subtracti...
<p>(A) Box-and-whisker plot of the number of gamma H2AX foci per nucleus for each tested dose and th...
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast m...
<p>This figure shows the survival probability of a LL cell line measured in a split dose experiment ...
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast m...
<p>(A) γ-H2AX intensity histograms for different irradiated fractions at 1 hour post exposure. (B) E...
(A) Representative immunofluorescence images of 387 GSCs harvested at 30 min, 24 hrs and 48 hours af...
Simulation of different experimental protocols consisting of spacing each single dose by a given num...
<p>(a) illustrates the dose effect curve. Samples were irradiated with doses ranging from 5 to 50 mG...