Comparison between the simulated and experimental distance distribution functions <i>P(r)</i> of Hsp70 s.

<p>A: Distance distribution function <i>P(r)</i> of the ATP-bound (green lines) and ADP-bound (blue lines) of <i>E. coli</i> DnaK computed from MD simulations (solid lines) and computed from the experimental X-ray (PDB ID: 4BQ9) <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003379#pcbi.1003379-Kityk1" target="_blank">[69]</a> and NMR-derived (PDB ID: 2KHO) <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003379#pcbi.1003379-Bertelsen1" target="_blank">[70]</a> structures (dashed lines), respectively. B: Distance distribution function <i>P(r)</i> of the ATP-bound (green line) and ADP-bound (blue line) of bHsc70. The function <i>P(r)</i> of bHsc70 in the ATP and ADP states were digitized from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003379#pcbi-1003379-g004" target="_blank">Figure 4</a> of Ref. <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003379#pcbi.1003379-Wilbanks1" target="_blank">[82]</a>.