The network model.

<p>Interactions among marker genes of ESCs, <i>Sox2</i>, <i>Oct4</i>, and <i>Nanog</i>, and lineage-specific genes, <i>Gata6</i>, <i>Cdx2</i>, and <i>Gcnf</i> are shown with black lines for formation of complexes of factors synthesized from the corresponding genes, red lines for activating the target genes, and blue lines for repressing the target genes. Experimental data used to infer the interactions are designated by numbers on lines, which are explained with the corresponding numbering in subsection <i>Inference of the network from experimental observations</i> in section <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003380#s4" target="_blank"><i>Methods</i></a>.