Transcriptomes of GATA4,6 double excised mice.

<p>Number of differentially expressed genes at different fold-change cutoffs with false discovery rate (FDR) thresholds < 25% (A), <20% (B, left) and <30% (B, right). Red or blue numbers indicate upregulated or downregulated genes, respectively. (C) ChIP-qPCR shows GATA4 occupancy at differentially expressed genes. (D) Relative mRNA levels of differentially expressed genes. n=4, ** p<0.05 by paired T test comparing fold change between AAV-Cre and AAV-GFP injected mice. (E) Ingenuity Pathway Analysis (IPA) shows enriched pathways of differentially expressed genes with FDR <30% and fold change >1.2. Note FDR and p-value on top row refer to values for specific pathways as determined by IPA. Bolded genes have at least one GATA4 OS within 10 kb upstream or downstream. FXR = farnesoid X receptor, RXR = retinoid X receptor.