Percentage of genes annotated with the indicated GO term in different HK and TS sets.

<p>The figure shows the percentages of genes annotated with the indicated enriched GO category (determined using FDR-corrected p<0.05) in the indicated HK or TS gene set. Genes not associated with any enriched GO term were not used to compute the percentage. At GO’s level 2 (left graph), ‘Localization’ (GO: 0051179) was the only enriched BP category common to both the HK and TS sets; however, at the next level (level 3) of this category (right graph), the enriched GO terms for the two gene sets were different. Note that, “cellular localization (GO: 0051641)” and “macromolecule localization (GO: 0033036)” denote that a protein or macromolecule is transported to a specific location in a cell, while “localization of cell (GO: 0051674)” denotes that a cell is transported to a specific location <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083040#pone.0083040-Chu1" target="_blank">[40]</a>. Similar results were obtained for the analysis using GO Cellular Component (CC) (Figure S4 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083040#pone.0083040.s001" target="_blank">File S1</a>) and Molecular Function (MF) categories (Figure S5 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083040#pone.0083040.s001" target="_blank">File S1</a>).