GO Analyses and Functional Grouping of the Molecular Backbone and Signatures

<div><p>(A) GO analyses of ~4,000 genes present and unchanged in all five fractions irrespective of lineage or cell type. Shown is the percentage of genes in a given GO category, compared to all genes of the signature of a given cell type. Note that the genes were enriched mostly in categories involved in basic cell functions representing the molecular backbone. Asterisks denote a significant increase over a whole genome prediction. NC, not changed.</p> <p>(B) GO analyses of the molecular signatures. The signature was defined as the genes whose expression was upregulated by ≥ 2× in only one of the five hair/backskin populations. Each signature was categorized into groups of genes depending upon their putative cellular functions. Shown is the percentage of genes in a given GO category, compared to all genes of the signature of a given cell type. Asterisks denote a significant increase over a whole genome prediction.</p> <p>(C) The molecular signatures. The gene abbreviations and/or accession numbers are according to the NCBI listings. # denotes genes implicated in skin/hair disorders. (P) denotes genes with appreciable signal but higher levels in one of the other four populations. For multiple genes in a signature, the abbreviation is listed once, followed by –x, where x is the specific gene number.</p>