Block of L- and P/Q-type -channels affects electrical activity differently.

<p>A: Spiking electrical activity is suppressed by L-type -channel block in the model with default parameters, and nS/pF during the period indicated by the gray bar. B: Spiking electrical activity is accelerated by the application of -agatoxin IVA in human -cells. Recordings from the same human -cell in 6 mM extracellular glucose before (left) and during (right) application of 200 nM -agatoxin IVA. C: Model simulation with default parameters of the membrane potential during spiking electrical activity under control conditions and after blockage of P/Q-type -channels ( nS/pF during the period indicated by the gray bar). D: In the model, the peak submembrane -concentration is lower when P/Q-type channels are blocked. E: The reduced activate less SK-current when P/Q-type channels are blocked.