Simulated electrical activity in the GLUTag cell line.

<p>A: Simulation of electrical activity triggered by SGLT1-substrate uptake, corresponding to <i>α</i>MG application, with default parameters and extracellular SGLT1-substrate concentration, <i>G</i>_SGLT1, changing from 0.5 mM to 1.5 mM and 10 mM as indicated. B: SGLT1-associated current (left axis) and average calcium current (red, right axis) corresponding to the simulation in panel A. C: Simulation of electrical activity triggered by K(ATP)-channel closure with default parameters and K(ATP)-channel conductance, <i>g</i>_{<i>K</i>(<i>ATP</i>)}, changed from from 30 pS/pF to 23 pS/pF as indicated by the bar. D: Voltage peak amplitude as a function of <i>G</i>_SGLT1 and <i>g</i>_{<i>K</i>(<i>ATP</i>)}. E: Spiking frequency as a function of <i>G</i>_SGLT1 and <i>g</i>_{<i>K</i>(<i>ATP</i>)}. In panels D and E, the black arrows indicate the parameter changes in panels A, B and C. The red arrow indicates the effect of an increase in intracellular glucose concentration due to GLUT2 transport.