<p>A, no staining (score, 0); B, faint staining (score, 1+); C, moderate staining (score, 2+); D, strong staining (score, 3+); E, ALK protein staining of patient with concurrent ALK and EGFR mutation (patient 1, score, 1+); F, ALK protein staining of patient with concurrent ALK and EGFR mutation (patient 2, score, 2+). Magnification, 400×.</p
BACKGROUND: Anaplastic lymphoma kinase (ALK) rearrangement represents a landmark in the targeted the...
<p>Dot lines correspond to that we also recommend initial ALK testing practice begins with IHC and f...
<p>A-B, Immunohistochemistry showed cytoplasmic immunoreactivity for ALK protein expression (A, 20×;...
<p>(A) negative staining, (B) ≤10% staining, (C) 50% staining, and (D) 80% staining of tumor cells.<...
<p>AJCC, American Joint Committee on Cancer; ALK, anaplastic lymphoma kinase; CNG, copy number gain;...
<p>A: H&E staining of a cell block shows lung carcinoma cells. B: Strong staining of ALK protein in ...
INTRODUCTION Diagnostic immunohistochemistry (IHC) is increasingly accepted as a screening method...
<p>ALK IHC reveals variable levels of protein expression: from absent (0) to weak/faint cytoplasmic ...
<p>(A) IHC score 3+ for strong, granular cytoplasmic staining in most of tumor cells, at least more ...
<p>The total EGFR protein in cytology samples could be stained with EGFR (D38B1) antibody (A, D and ...
<p>Percentage staining was scored on a scale of 0 to 4, where 0 = no staining, 1 = less than 25%, 2 ...
Background: Identification of targetable EML4-ALK fusion proteins has revolutionized the treatment o...
<p>Representative immunostaining of both histology and cytology samples in NSCLC patients (<b>A</b>,...
<p>(A) An <i>ALK-</i>negative case without cytoplasmic staining. (B) An <i>EML4-ALK-</i>positive cas...
<p>A-B, Immunohistochemistry showed cytoplasmic immunoreactivity for ALK protein expression (A, 20×;...
BACKGROUND: Anaplastic lymphoma kinase (ALK) rearrangement represents a landmark in the targeted the...
<p>Dot lines correspond to that we also recommend initial ALK testing practice begins with IHC and f...
<p>A-B, Immunohistochemistry showed cytoplasmic immunoreactivity for ALK protein expression (A, 20×;...
<p>(A) negative staining, (B) ≤10% staining, (C) 50% staining, and (D) 80% staining of tumor cells.<...
<p>AJCC, American Joint Committee on Cancer; ALK, anaplastic lymphoma kinase; CNG, copy number gain;...
<p>A: H&E staining of a cell block shows lung carcinoma cells. B: Strong staining of ALK protein in ...
INTRODUCTION Diagnostic immunohistochemistry (IHC) is increasingly accepted as a screening method...
<p>ALK IHC reveals variable levels of protein expression: from absent (0) to weak/faint cytoplasmic ...
<p>(A) IHC score 3+ for strong, granular cytoplasmic staining in most of tumor cells, at least more ...
<p>The total EGFR protein in cytology samples could be stained with EGFR (D38B1) antibody (A, D and ...
<p>Percentage staining was scored on a scale of 0 to 4, where 0 = no staining, 1 = less than 25%, 2 ...
Background: Identification of targetable EML4-ALK fusion proteins has revolutionized the treatment o...
<p>Representative immunostaining of both histology and cytology samples in NSCLC patients (<b>A</b>,...
<p>(A) An <i>ALK-</i>negative case without cytoplasmic staining. (B) An <i>EML4-ALK-</i>positive cas...
<p>A-B, Immunohistochemistry showed cytoplasmic immunoreactivity for ALK protein expression (A, 20×;...
BACKGROUND: Anaplastic lymphoma kinase (ALK) rearrangement represents a landmark in the targeted the...
<p>Dot lines correspond to that we also recommend initial ALK testing practice begins with IHC and f...
<p>A-B, Immunohistochemistry showed cytoplasmic immunoreactivity for ALK protein expression (A, 20×;...