Detection of ALK rearrangements using Ventana immunohistochemistry (IHC) (200×).

A Comparison of Immunohistochemical Assays and FISH in Detecting the ALK Translocation in Diagnostic Histological and Cytological Lung Tumor Material

Le Quesne, John
Maurya, Manisha
Yancheva, Slaveya G.
O’Brien, Mary
Popat, Sanjay
Wotherspoon, Andrew C.
de Castro, David Gonzalez
Nicholson, Andrew G.

June 2014

Introduction:Detection of the ALK rearrangement in a solid tumor gives these patients the option of ...

ALK immunohistochemical staining.

Ning-Ning Zhang (505747)
Yu-Tao Liu (505748)
Li Ma (46633)
Lin Wang (11986)
Xue-Zhi Hao (505749)
Zheng Yuan (59323)
Dong-Mei Lin (505750)
Dan Li (106345)
Yu-Jie Zhou (505751)
Hua Lin (505752)
Xiao-Hong Han (505753)
Yan Sun (22436)
Yuankai Shi (495418)

January 2014

A, no staining (score, 0); B, faint staining (score, 1+); C, moderate staining (score, 2+); D, st...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette M.
Weremowicz, Stanislawa
Gray, Stacy W.
Wong, Kwok-Kin
Chirieac, Lucian R.
Lindeman, Neal I.
Hornick, Jason L.

March 2013

IntroductionALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leadin...

Application of Ventana immunocytochemical analysis on ThinPrep cytology slides for detection of ALK rearrangement in patients with advanced non–small-cell lung cancer

Hui Qin Guo
Jia Jia
Lin Lin Zhao
Huan Zhao
Cong Wang
Yue Sun
Jian Ming Ying
Lei Guo
Jian Cao
Zhi Hui Zhang

December 2018

Abstract Background Ventana ALK (D5F3) screening of anaplastic lymphoma kinase (ALK) gene rearrangem...

Detection of ALK rearrangements using Fluorescent in situ hybridization (FISH) (1000×).

Jinghui Wang (620961)
Yiran Cai (2225728)
Yujie Dong (2225722)
Jingying Nong (2225731)
Lijuan Zhou (131287)
Guimei Liu (2225725)
Dan Su (8007)
Xi Li (19208)
Shafei Wu (827873)
Xuejing Chen (1536997)
Na Qin (774536)
Xuan Zeng (417018)
Haiqing Zhang (34503)
Zongde Zhang (422658)
Shucai Zhang (829370)

July 2014

(A) An ALK-negative case. (B) An ALK-positive case with split signal pattern. (C) A...

Assessment of ALK Rearrangement in Non-small Cell Lung Cancer: Using Enhancing Immunohistochemical Way and Fluorescence in situ Hybridization

Hui MENG
Xianzheng GAO
Lan ZHANG
Fang LIU
Wencai LI

February 2015

Background and objective Besides epidermal growth factor receptor (EGFR) mutation, the non-small cel...

Immunostaining pattern of ALK in NSCLC using Ventana anti-ALK (D5F3) and Novocastra (5A4) antibodies.

Esther Conde (289601)
Ana Suárez-Gauthier (310293)
Amparo Benito (632844)
Pilar Garrido (632845)
Rosario García-Campelo (632846)
Michele Biscuola (126322)
Luis Paz-Ares (310297)
David Hardisson (262959)
Javier de Castro (257472)
M. Carmen Camacho (632847)
Delvys Rodriguez-Abreu (632848)
Ihab Abdulkader (152334)
Josep Ramirez (594690)
Noemí Reguart (5660632)
Marta Salido (58579)
Lara Pijuán (632849)
Edurne Arriola (632850)
Julián Sanz (3855316)
Victoria Folgueras (632851)
Noemí Villanueva (632852)
Javier Gómez-Román (3405617)
Manuel Hidalgo (7235)
Fernando López-Ríos (5651923)

September 2014

ALK IHC reveals variable levels of protein expression: from absent (0) to weak/faint cytoplasmic ...

ALK-rearranged lung adenocarcinoma without EML4-ALK and KIF5B-ALK.

Yuki Togashi (184594)
Manabu Soda (184596)
Seiji Sakata (184597)
Emiko Sugawara (184599)
Satoko Hatano (184604)
Reimi Asaka (184607)
Takashi Nakajima (184610)
Hiroyuki Mano (184613)
Kengo Takeuchi (184615)

February 2012

Panel A shows the results of anti-ALK immunohistochemistry with the iAEP method on pulmonary aden...

Detection of ALK Rearrangement by Immunohistochemistry in Lung Adenocarcinoma and the Identification of a Novel EML4-ALK Variant

To, Ka-Fai
Tong, Joanna HM
Yeung, King SF
Lung, Raymond WM
Law, Peggy PY
Chau, Shuk Ling
Kang, Wei
Tong, Carol YK
Chow, Chit
Chan, Anthony WH
Leung, Linda KS
Mok, Tony SK

July 2013

IntroductionThe echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-AL...

Evaluation of ALK Rearrangement in Chinese Non-Small Cell Lung Cancer Using FISH, Immunohistochemistry, and Real-Time Quantitative RT- PCR on Paraffin-Embedded Tissues

Zhang, Yun-Gang
Jin, Mu-Lan
Li, Li
Zhao, Hong-Ying
Zeng, Xuan
Jiang, Lei
Wei, Ping
Diao, Xiao-Li
Li, Xue
Cao, Qing
Tian, Xin-Xia

January 2013

Patients with ALK gene rearrangements often manifest dramatic responses to crizotinib, an ALK inhibi...

Evaluation of ALK Rearrangement in Chinese Non-Small Cell Lung Cancer Using FISH, Immunohistochemistry, and Real-Time Quantitative RT- PCR on Paraffin- Embedded Tissues

Yun-gang Zhang
Mu-lan Jin
Li Li
Hong-ying Zhao
Xuan Zeng
Lei Jiang
Ping Wei
Li Diao
Xue Li
Qing Cao
Xin-xia Tian

August 2016

Patients with ALK gene rearrangements often manifest dramatic responses to crizotinib, an ALK inhibi...

Representative examples of Ventana immunohistochemical staining of ALK.

Leilei Liu (704957)
Ping Zhan (327107)
Xiaodie Zhou (704958)
Yong Song (286107)
Xiaojun Zhou (16139)
Like Yu (139446)
Jiandong Wang (596249)

March 2015

A: H&E staining of a cell block shows lung carcinoma cells. B: Strong staining of ALK protein in ...

Detection of ALK and ROS1 rearrangements by immunocytochemistry on cytological samples

Frankel, Diane
Bourlard, Donatienne
Garcia, Stephane
Robaglia-Schlupp, Andrée
Peker, Emel
Groliere, Adele
Kaspi, Elise
Roll, Patrice

January 2019

International audienceThe identification of ALK and ROS1 rearrangements has become essential for the...

Diagnostic algorithm for the identification of ALK rearrangement in lung cancer.

Kazuya Takamochi (440443)
Kengo Takeuchi (184615)
Takuo Hayashi (440444)
Shiaki Oh (440445)
Kenji Suzuki (157178)

August 2013

For cases with iScore 3 or 0, confirmatory FISH or RT-PCR can be skipped. However, if a case with...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette Marie
Weremowicz, Stanislawa
Gray, Stacy
Wong, Kwok-Kin
Chirieac, Lucian Radu
Lindeman, Neal I.
Hornick, Jason L.

May 2017

INTRODUCTION ALK gene rearrangements occur in ~5% of lung adenocarcinomas (ACA), leading to ALK ove...

A Comparison of Immunohistochemical Assays and FISH in Detecting the ALK Translocation in Diagnostic Histological and Cytological Lung Tumor Material

Le Quesne, John
Maurya, Manisha
Yancheva, Slaveya G.
O’Brien, Mary
Popat, Sanjay
Wotherspoon, Andrew C.
de Castro, David Gonzalez
Nicholson, Andrew G.

June 2014

Introduction:Detection of the ALK rearrangement in a solid tumor gives these patients the option of ...

ALK immunohistochemical staining.

Ning-Ning Zhang (505747)
Yu-Tao Liu (505748)
Li Ma (46633)
Lin Wang (11986)
Xue-Zhi Hao (505749)
Zheng Yuan (59323)
Dong-Mei Lin (505750)
Dan Li (106345)
Yu-Jie Zhou (505751)
Hua Lin (505752)
Xiao-Hong Han (505753)
Yan Sun (22436)
Yuankai Shi (495418)

January 2014

A, no staining (score, 0); B, faint staining (score, 1+); C, moderate staining (score, 2+); D, st...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette M.
Weremowicz, Stanislawa
Gray, Stacy W.
Wong, Kwok-Kin
Chirieac, Lucian R.
Lindeman, Neal I.
Hornick, Jason L.

March 2013

IntroductionALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leadin...

Application of Ventana immunocytochemical analysis on ThinPrep cytology slides for detection of ALK rearrangement in patients with advanced non–small-cell lung cancer

Hui Qin Guo
Jia Jia
Lin Lin Zhao
Huan Zhao
Cong Wang
Yue Sun
Jian Ming Ying
Lei Guo
Jian Cao
Zhi Hui Zhang

December 2018

Abstract Background Ventana ALK (D5F3) screening of anaplastic lymphoma kinase (ALK) gene rearrangem...

Detection of ALK rearrangements using Fluorescent in situ hybridization (FISH) (1000×).

Jinghui Wang (620961)
Yiran Cai (2225728)
Yujie Dong (2225722)
Jingying Nong (2225731)
Lijuan Zhou (131287)
Guimei Liu (2225725)
Dan Su (8007)
Xi Li (19208)
Shafei Wu (827873)
Xuejing Chen (1536997)
Na Qin (774536)
Xuan Zeng (417018)
Haiqing Zhang (34503)
Zongde Zhang (422658)
Shucai Zhang (829370)

July 2014

(A) An ALK-negative case. (B) An ALK-positive case with split signal pattern. (C) A...

Assessment of ALK Rearrangement in Non-small Cell Lung Cancer: Using Enhancing Immunohistochemical Way and Fluorescence in situ Hybridization

Hui MENG
Xianzheng GAO
Lan ZHANG
Fang LIU
Wencai LI

February 2015

Background and objective Besides epidermal growth factor receptor (EGFR) mutation, the non-small cel...

Immunostaining pattern of ALK in NSCLC using Ventana anti-ALK (D5F3) and Novocastra (5A4) antibodies.

Esther Conde (289601)
Ana Suárez-Gauthier (310293)
Amparo Benito (632844)
Pilar Garrido (632845)
Rosario García-Campelo (632846)
Michele Biscuola (126322)
Luis Paz-Ares (310297)
David Hardisson (262959)
Javier de Castro (257472)
M. Carmen Camacho (632847)
Delvys Rodriguez-Abreu (632848)
Ihab Abdulkader (152334)
Josep Ramirez (594690)
Noemí Reguart (5660632)
Marta Salido (58579)
Lara Pijuán (632849)
Edurne Arriola (632850)
Julián Sanz (3855316)
Victoria Folgueras (632851)
Noemí Villanueva (632852)
Javier Gómez-Román (3405617)
Manuel Hidalgo (7235)
Fernando López-Ríos (5651923)

September 2014

ALK IHC reveals variable levels of protein expression: from absent (0) to weak/faint cytoplasmic ...

ALK-rearranged lung adenocarcinoma without EML4-ALK and KIF5B-ALK.

Yuki Togashi (184594)
Manabu Soda (184596)
Seiji Sakata (184597)
Emiko Sugawara (184599)
Satoko Hatano (184604)
Reimi Asaka (184607)
Takashi Nakajima (184610)
Hiroyuki Mano (184613)
Kengo Takeuchi (184615)

February 2012

Panel A shows the results of anti-ALK immunohistochemistry with the iAEP method on pulmonary aden...

Detection of ALK Rearrangement by Immunohistochemistry in Lung Adenocarcinoma and the Identification of a Novel EML4-ALK Variant

To, Ka-Fai
Tong, Joanna HM
Yeung, King SF
Lung, Raymond WM
Law, Peggy PY
Chau, Shuk Ling
Kang, Wei
Tong, Carol YK
Chow, Chit
Chan, Anthony WH
Leung, Linda KS
Mok, Tony SK

July 2013

IntroductionThe echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-AL...

Evaluation of ALK Rearrangement in Chinese Non-Small Cell Lung Cancer Using FISH, Immunohistochemistry, and Real-Time Quantitative RT- PCR on Paraffin-Embedded Tissues

Zhang, Yun-Gang
Jin, Mu-Lan
Li, Li
Zhao, Hong-Ying
Zeng, Xuan
Jiang, Lei
Wei, Ping
Diao, Xiao-Li
Li, Xue
Cao, Qing
Tian, Xin-Xia

January 2013

Patients with ALK gene rearrangements often manifest dramatic responses to crizotinib, an ALK inhibi...

Evaluation of ALK Rearrangement in Chinese Non-Small Cell Lung Cancer Using FISH, Immunohistochemistry, and Real-Time Quantitative RT- PCR on Paraffin- Embedded Tissues

Yun-gang Zhang
Mu-lan Jin
Li Li
Hong-ying Zhao
Xuan Zeng
Lei Jiang
Ping Wei
Li Diao
Xue Li
Qing Cao
Xin-xia Tian

August 2016

Patients with ALK gene rearrangements often manifest dramatic responses to crizotinib, an ALK inhibi...

Representative examples of Ventana immunohistochemical staining of ALK.

Leilei Liu (704957)
Ping Zhan (327107)
Xiaodie Zhou (704958)
Yong Song (286107)
Xiaojun Zhou (16139)
Like Yu (139446)
Jiandong Wang (596249)

March 2015

A: H&E staining of a cell block shows lung carcinoma cells. B: Strong staining of ALK protein in ...

Detection of ALK and ROS1 rearrangements by immunocytochemistry on cytological samples

Frankel, Diane
Bourlard, Donatienne
Garcia, Stephane
Robaglia-Schlupp, Andrée
Peker, Emel
Groliere, Adele
Kaspi, Elise
Roll, Patrice

January 2019

International audienceThe identification of ALK and ROS1 rearrangements has become essential for the...

Diagnostic algorithm for the identification of ALK rearrangement in lung cancer.

Kazuya Takamochi (440443)
Kengo Takeuchi (184615)
Takuo Hayashi (440444)
Shiaki Oh (440445)
Kenji Suzuki (157178)

August 2013

For cases with iScore 3 or 0, confirmatory FISH or RT-PCR can be skipped. However, if a case with...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette Marie
Weremowicz, Stanislawa
Gray, Stacy
Wong, Kwok-Kin
Chirieac, Lucian Radu
Lindeman, Neal I.
Hornick, Jason L.

May 2017

INTRODUCTION ALK gene rearrangements occur in ~5% of lung adenocarcinomas (ACA), leading to ALK ove...

A Comparison of Immunohistochemical Assays and FISH in Detecting the ALK Translocation in Diagnostic Histological and Cytological Lung Tumor Material

Le Quesne, John
Maurya, Manisha
Yancheva, Slaveya G.
O’Brien, Mary
Popat, Sanjay
Wotherspoon, Andrew C.
de Castro, David Gonzalez
Nicholson, Andrew G.

June 2014

Introduction:Detection of the ALK rearrangement in a solid tumor gives these patients the option of ...

ALK immunohistochemical staining.

Ning-Ning Zhang (505747)
Yu-Tao Liu (505748)
Li Ma (46633)
Lin Wang (11986)
Xue-Zhi Hao (505749)
Zheng Yuan (59323)
Dong-Mei Lin (505750)
Dan Li (106345)
Yu-Jie Zhou (505751)
Hua Lin (505752)
Xiao-Hong Han (505753)
Yan Sun (22436)
Yuankai Shi (495418)

January 2014

A, no staining (score, 0); B, faint staining (score, 1+); C, moderate staining (score, 2+); D, st...

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas

Sholl, Lynette M.
Weremowicz, Stanislawa
Gray, Stacy W.
Wong, Kwok-Kin
Chirieac, Lucian R.
Lindeman, Neal I.
Hornick, Jason L.

March 2013

IntroductionALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leadin...

Detection of <i>ALK</i> rearrangements using Ventana immunohistochemistry (IHC) (200×).

Abstract

Extracted data

Detection of <i>ALK</i> rearrangements using Ventana immunohistochemistry (IHC) (200×).

Abstract

Extracted data

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