DED is spatially localized.

<p>(A, B, C and D) Top panels display the dendritic location used for dendritic stimulation (blue circle) and the range of possible report locations (white dotted lines). Bottom panels show example current measurements before (black) and after stimulation (grey or blue) as well normalized current before and after stimulation. Following proximal dendritic stimulation, (A) proximal dendritic current decreases (DED = 2.94%±2.19%, p<001, n = 11/12) (B) somatic current shows increase in excitability by 4.89%±1.89 (p<0.001 n = 10/10) (C) Un-stimulated dendrites don't show DED (%DED = 0.05%±2.93%, p = 0.22, n = 10/10) and (D) Current resulting from whole cell photo-stimulation does not change significantly (DED = −0.4%±1.9, n = 9/9, p = 0.10).