Realistic modeling of puzzling experimental findings.

<p><b>a</b>) the 3D reconstruction used in most simulations (<i>left</i>, cell ri06 from the neuromorpho.org database), and model fitting (<i>green</i>) of simultaneous dendritic and somatic experimental recordings (<i>black</i>); dendritic current injection (1 nA, 200 ms, ∼200 µm from soma); cell’s scale bar is 100 µm; <b>b</b>) (<i>left</i>) Typical peak somatic depolarization reached during dendritic stimulations in an experiments with (<i>red</i>) or without (<i>blue</i>) <i>I_h</i>; inset shows somatic recordings for a 60 µA stimulus; (<i>right</i>) Peak somatic depolarization with or without <i>I_h</i> after block of <i>K_M</i>. Experimental results in panel <i>b</i> report results observed in different CA1 neurons, and were adapted from Figs. 2b and 6c of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036867#pone.0036867-George1" target="_blank">[5]</a> with permission from Macmillan Publishers Ltd, copyright (2009).