<i>Bmp6</i> and <i>Hamp1</i> expression decreases in the livers of <i>Fpn1^Alb/Alb</i> mice with high iron demand.

<p>(A) Liver and spleen non-heme iron concentrations. (B) SI and TS%. (C–E) Liver mRNA levels of <i>Hamp1</i> (C), <i>Bmp6</i> (D), <i>Epo</i> (E). and (F) Liver p-Smad1/5/8, Smad1, p-Erk1/2, Erk1/2, p-Stat3, Stat3 and β-actin protein levels were measured in 3-week-old male <i>Fpn1^flox/flox</i> and <i>Fpn1^Alb/Alb</i> mice fed an iron-rich diet for one week, and then transferred to an iron-deficient diet for one month (n = 5 per group). (G) Summary of the results in (F), quantitated using densitometry. Summary data are presented as mean ± SD. <b>*</b>P<0.05; <b>**</b>P<0.01.