Signal distribution over the mitochondrial genome in human FAIRE-seq, DNAse-seq and MNAse-seq datasets.

<p>Shown is the maximum z-score for each individual replicate for each cell line (left) and the z-score profile along the mitochondrial chromosome for the replicate with the highest z-score (right). (A) FAIRE data; (B) DNAse data; (C) MNAse data. “UNC”, “UW” and “SYDH” refer to the ENCODE production groups which generated the data. Z-scores larger than 100 are shown as 100. No read enrichment over the D-loop is observed, suggesting that the D-loop signal found in TF ChIP-seq datasets is not due to sequencing biases but is a result of the immunoprecipitation process.