Disruption of FGFR1-Frs2/3 pathway decreases the number of vestibular hair cells.
- Kazuya Ono (513633)
- Tomoko Kita (513634)
- Shigeru Sato (80281)
- Paul O'Neill (513635)
- Siu-Shan Mak (513636)
- Marie Paschaki (179823)
- Masataka Ito (309625)
- Noriko Gotoh (133877)
- Kiyoshi Kawakami (513637)
- Yoshiki Sasai (106589)
- Raj K. Ladher (513638)
Publication date
January 2014
DOIAbstract
<p>(A, B) No change in HC number was detected between E16.5 <i>Six1enh21-Cre::Fgfr1<sup>flox/+</sup></i> (A) and <i>Six1enh21-Cre::Fgfr1<sup>flox/flox</sup></i> utricles (B) labeled with anti-Myo7a antibody. (C, D) Fewer HCs were observed in the utricle of E16.5 <i>Fgfr1</i><sup>Δ<i>Frs/</i>Δ<i>Frs</i></sup> mutants (D) than <i>Fgfr1</i><sup>Δ<i>Frs/+</i></sup> control (C). Ampullary HCs are also included (asterisks). Scale bar: A–D; 200 µm (in D).</p
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