A carton illustrates association of surface PDGFRA with cell proliferation via ERK signaling pathway in glioma cells.

<p>Even in the absence of acute ligand stimulation, PDGFRA is constitutively, but slowly trafficking in glioma cells. In this trafficking process, PDGFRA is transported in vesicles as cargo along cytoskeleton highway. The extent of endocytosis and recycling of PDGFRA is sensed by the ERK activity. High ERK activity could lead to changes resulting in enhanced endocytosis but diminished recycling, with PDGFRA enriched in Golgi apparatus. As a consequence, surface PDGFRA expression is down-regulated. This process would dampen the ligand stimulation.