<p>STEPact, non-phosphorylated STEP over total STEP; D32p34, DARPP32 phosphorylated in threonine 34; D32p75, DARPP32 phosphorylated in threonine 75; PFC, prefrontal cortex; APA, acute psychostimulant administration; WT, wild type; IB, immunoblot; ERKpp, active ERK; GluR1p, AMPAR subunit GluR1 phosphorylated in the PKA site; t. series, time series; Monoexp, monoexponential. The names of the phenotypic variables are built from the name and marker columns except for parameterized time series or dose responses where it is used the parameter name instead of the marker.</p
textabstractBackground: Establishing preclinical models is essential for novel drug discovery in sch...
Phenotypic screening is a type of screening used to identify substances such as small molecules, pep...
<p>Each representation consists of average responses of raw RPPA, low-rank component and sparse comp...
(A) Fold Change mRNA trajectories for PPRR increases of 0.5 (green), 2 (cerulean), 5 (red), 10 (blue...
<p>A) Ligand-receptor cooperativity for RTK submodel (dots-deterministic simulations; lines- hill eq...
High-throughput screening of drug response in cultured cell lines is essential for studying therapeu...
<p>(A) Schematic of model for NGF-induced Erk1/2 signalling. Arrows represent conversion reactions a...
<p>(A) Late response (58 min) phenotypes for Total AP-1 transcription factor (TF) shown as High, Mid...
<p>(A) Schematic of model for NGF-induced Erk1/2 signalling. Arrows represent conversion reactions a...
<p>A) Simulated heterogeneity in Syk phosphorylation. The simulated distribution (black line) is com...
<p>Phosphorylated and total ERK1/2 levels in the striatum were measured by Western blot analysis. (A...
<p>Solid lines indicate the simulated model dynamics with the optimal parameter values. Gray shading...
<p>Tumors (x axis) were grouped by AKT class then Z transformed mRNA (A) or protein and phospho-prot...
<p><b>A.</b> and <b>B.</b> Bar graphs show the time-dependent changes in the phosphorylation status ...
<p>(a,b) Calculated intact (solid line) and N-only (dashed line) following IV (black) or SC (red) ad...
textabstractBackground: Establishing preclinical models is essential for novel drug discovery in sch...
Phenotypic screening is a type of screening used to identify substances such as small molecules, pep...
<p>Each representation consists of average responses of raw RPPA, low-rank component and sparse comp...
(A) Fold Change mRNA trajectories for PPRR increases of 0.5 (green), 2 (cerulean), 5 (red), 10 (blue...
<p>A) Ligand-receptor cooperativity for RTK submodel (dots-deterministic simulations; lines- hill eq...
High-throughput screening of drug response in cultured cell lines is essential for studying therapeu...
<p>(A) Schematic of model for NGF-induced Erk1/2 signalling. Arrows represent conversion reactions a...
<p>(A) Late response (58 min) phenotypes for Total AP-1 transcription factor (TF) shown as High, Mid...
<p>(A) Schematic of model for NGF-induced Erk1/2 signalling. Arrows represent conversion reactions a...
<p>A) Simulated heterogeneity in Syk phosphorylation. The simulated distribution (black line) is com...
<p>Phosphorylated and total ERK1/2 levels in the striatum were measured by Western blot analysis. (A...
<p>Solid lines indicate the simulated model dynamics with the optimal parameter values. Gray shading...
<p>Tumors (x axis) were grouped by AKT class then Z transformed mRNA (A) or protein and phospho-prot...
<p><b>A.</b> and <b>B.</b> Bar graphs show the time-dependent changes in the phosphorylation status ...
<p>(a,b) Calculated intact (solid line) and N-only (dashed line) following IV (black) or SC (red) ad...
textabstractBackground: Establishing preclinical models is essential for novel drug discovery in sch...
Phenotypic screening is a type of screening used to identify substances such as small molecules, pep...
<p>Each representation consists of average responses of raw RPPA, low-rank component and sparse comp...