AD-mice injected with aggregate-depleted samples show lower levels of insoluble Aβ42 in their brains.

<p>Frozen hippocampi were homogenized and the quantity of aggregated Aβ42 was measured by ELISA after formic acid extraction as explained in the Materials and Methods section. The quantity of insoluble Aβ₄₂ was measured using ELISA kits designed to specifically detect this peptide. The values shown correspond to the means ± SEM. * P<0.05.