<p><b>Bold</b> denotes measured affinity improvements, or specificity changes, greater than 3-fold.</p>1<p>Improvement in binding association constant relative to wild-type (K<sub>D</sub>_mut/K<sub>D</sub>_wt).</p>2<p>Specificity change toward AAG versus ELA peptide: Fold_Change AAG/Fold_Change_ELA.</p
<p>Sequence selection, fold specificity, and approximate binding affinity results for all 17 peptide...
a<p>Mutations to the wild type <i>algD</i> binding site are notated by the bolded nucleotides in eac...
<p>Mutations were modeled in Rosetta without minimization (a, b) or with minimization of interface b...
<p>Scores were produced using fixed backbone and fixed neighboring side chains (ZF, Ros) or minimiza...
<p>IC<sub>50</sub> values are plotted as cognate wild type and variant pairs, where lower IC<sub>50<...
<p>Fold-increase indicates the ratio of binding affinities between the mutants and wild-type decoy r...
<p>(a) Steady-state binding equilibrium data for ELA/HLA-A2 binding wild type DMF5 and the βL98W and...
<p>Binding affinities (K<sub>D</sub>) of the single mutants for MD2 were measured from the associati...
Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human genome. Almost all p...
AbstractHLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound peptides in endocy...
The polymorphism at position beta69 of the human leukocyte antigen (HLA)-DP molecule has been associ...
AbstractHLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound peptides in endocy...
<p>(<b>Top row</b>) Effect of mutations on binding affinity to HLA-A molecules according to two alte...
<p>(a) Superposition of the YW/ELA/HLA-A2 and the DMF5/ELA/HLA-A2 complexes. DMF5 α chain is yellow,...
Antibodies are widely used not only as therapeutic agents but also as research tools and diagnostic ...
<p>Sequence selection, fold specificity, and approximate binding affinity results for all 17 peptide...
a<p>Mutations to the wild type <i>algD</i> binding site are notated by the bolded nucleotides in eac...
<p>Mutations were modeled in Rosetta without minimization (a, b) or with minimization of interface b...
<p>Scores were produced using fixed backbone and fixed neighboring side chains (ZF, Ros) or minimiza...
<p>IC<sub>50</sub> values are plotted as cognate wild type and variant pairs, where lower IC<sub>50<...
<p>Fold-increase indicates the ratio of binding affinities between the mutants and wild-type decoy r...
<p>(a) Steady-state binding equilibrium data for ELA/HLA-A2 binding wild type DMF5 and the βL98W and...
<p>Binding affinities (K<sub>D</sub>) of the single mutants for MD2 were measured from the associati...
Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human genome. Almost all p...
AbstractHLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound peptides in endocy...
The polymorphism at position beta69 of the human leukocyte antigen (HLA)-DP molecule has been associ...
AbstractHLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound peptides in endocy...
<p>(<b>Top row</b>) Effect of mutations on binding affinity to HLA-A molecules according to two alte...
<p>(a) Superposition of the YW/ELA/HLA-A2 and the DMF5/ELA/HLA-A2 complexes. DMF5 α chain is yellow,...
Antibodies are widely used not only as therapeutic agents but also as research tools and diagnostic ...
<p>Sequence selection, fold specificity, and approximate binding affinity results for all 17 peptide...
a<p>Mutations to the wild type <i>algD</i> binding site are notated by the bolded nucleotides in eac...
<p>Mutations were modeled in Rosetta without minimization (a, b) or with minimization of interface b...