Defining adequate performance based on volume.

<p>Plots demonstrate our method for constructing curves by using the benchmark threshold as the limit of 95% confidence based on volume: (A) CDR performance levels are established using 2.4 as the lower boundary for 95% CI of adequate performance (CIs shown) and the upper boundary for inadequate performance (CIs not shown). This methodology shows (indicated with a black dot) that a volume of 2770 is required to confidently assert the CDR benchmark median of 4.4/1000 is adequate; (B) RR performance levels are established using 16.8 as the upper boundary for 95% CI of adequate (CI shown) and inadequate (CI not shown) performance. A volume of 120 (indicated with a black dot) is required to confidently assert the RR benchmark median of 9.7% is adequate. Plots define regions of adequate, uncertain, and inadequate performance for (B) CDR and (D) RR.