Obesity and macrophage influx in adipose tissue of HFD-fed WT and MAP3K8-ko animals.
- Dov B. Ballak (526628)
- Peter van Essen (526629)
- Janna A. van Diepen (526630)
- Henry Jansen (526631)
- Anneke Hijmans (526632)
- Tetsuya Matsuguchi (519531)
- Helmut Sparrer (526633)
- Cees J. Tack (345136)
- Mihai G. Netea (105648)
- Leo A. B. Joosten (195019)
- Rinke Stienstra (24050)
Publication date
February 2014
DOIAbstract
<p>MAP3K8-ko and WT mice were fed a LFD or HFD during 16 weeks. (a) Bodyweight development upon LFD or HFD feeding. (b) Epididymal white adipose tissue (eWAT) weight after 16 weeks of LFD or HFD. (c) Liver weight after 16 weeks of LFD or HFD. (d) Plasma CXCL1 levels after 16 weeks of LFD or HFD (e) Macrophage influx into the adipose tissue as determined by immunohistochemistry, F4/80 (serotec) staining: 20× magnification or 40× as indicated: (f) Number of crown-like structures per field. (g–i) qPCR analysis for macrophage infiltration markers, (g) CD68, (h) F4/80, (i) MCP-1 in adipose tissue of MAP3K8-ko and WT animals. * p<0.05, ** p<0.01, *** p<0.001.</p
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