Treatment with LXA₄ decreases endometriotic lesion growth.

<p><b>A.</b> Representative pictures of a mouse with endometriotic lesions treated with vehicle (Veh, left panel) or LXA₄ (right panel) for 21 days. Six uterine biopsies were implanted on the peritoneal wall, 3 on each side, in a minimum of 20 mice which were randomly divided into two groups: Veh- and LXA₄-treated. Implanted tissues grew into enlarged cyst-like lesions by 21 days after endometriosis induction in the Veh group, while LXA₄ treatment significantly reduced lesion size. <b>B</b>. Graphical representation of endometriotic lesions volume, in mm³ ± SEM (**p<0.01). <b>C.</b> Morphology of formalin-fixed, paraffin-embedded lesion sections stained with HE. Upper panels a. and b. Vehicle-treated mouse with endometriosis. Lower panels c. and d. LXA₄-treated mouse with endometriosis. Images are representative of ten biological replicates.