Histological examination of human endometrial implants in nude mice two weeks after inoculation of endometrial tissue.

<p>A) Initial endometrial tissue before inoculation into mice. B) Endometrial implant 12 days following tissue inoculation showing epithelial glands (EG) surrounded by endometrial stromal cells (S) and mouse tissue (MT). Hematoxylin-eosin staining; scale bar, 20 µm. C and D) Effect of endometrial tissue inoculation and treatment with ISO-1 on the survival rate of animals. E and F) Effect of endometrial tissue inoculation and treatment with ISO-1 on the body weight of animals. The Figure summarizes results obtained from 7 mice treated with ISO-1 (4 mg/kg) and 8 control mice treated with vehicle.