Golgi-Cox analysis of neocortical and hippocampal neurons.

<p>A–H) Low- (A–D) and high-power (E–H) microphotographs of Golgiimpregnated neocortical (A–B, E–H) and hippocampal (C–D) neurons from MDP-3m (A, C, E, G) and epileptic MP-3m (B, D, F, H) rats. Note the dramatic and diffuse loss of dendritic arbors (B, D <i>vs</i> A, C), increase of both soma size and apical dendrite thickness (F <i>vs</i> E), and loss of spines (H <i>vs</i> G) in neurons from epileptic MP-3m <i>vs</i> non-epileptic MDP-3m rats. Dendrite fragmentations (black arrowhead in H), constrictions (white arrowhead in H) and varicosities (arrows in H, inset) are evident in higher magnification images. Dotted red and blue lines mark CA pyramidal and granule cell layers, respectively (C–D). Scale bars: A–B and C–D, 100 µm; E–H and inset, 10 µm.