NS2-specific aptamers do not trigger innate immunity in HCV-infected Huh7.5 cells.

<p>HCV-infected Huh7.5 cells were treated by 100 nM aptamer or library for 24, 48 hours. Total cellular RNA was isolated. The level of IFN-β (<b>A</b>), G1P3 (<b>B</b>) and 18U (<b>C</b>) mRNA was quantified by real-time PCR and normalized with GAPDH respectively. IFN-a treatment was used as positive control. The data represented means of three different experiments. *<i>P</i><0.05, **<i>P</i><0.01, *** <i>P</i><0.001 verse library.