Differential regulation of miRNA expressions in primary cortical neurons by sAβ and fAβ.

<p>The 14 DIV rat primary neurons were either untreated or treated for 24(<b>A</b>) CHO or 7PA2 CM (n = 6); (<b>B</b>) 5 µM fAβ_25–35 or fAβ_1–42 (n = 4); <b>(C)</b> 100 nM, 1 µM or 5 µM synthetic sAβ_1–42 (n = 3); <b>(D)</b> 100 nM, 1 µM or 5 µM synthetic sAβ_25–35 (n = 3). qRT-PCR data were normalized to 5S rRNA. Two-tailed Student's <i>t</i>-test was used for statistical comparison for panels A and B. Two-way ANOVA followed by bonferroni post-test was used for panels C and D: *p<0.05, **p<0.01, ***p<0.001.