Supervised hierarchical clustering for DMFS.

<p>Each row represents an mRNA and each column represents a patient sample. The mRNA clustering tree is shown on the left, and the sample clustering tree appears at the top. The colour scale shown at the bottom illustrates the relative expression level of an mRNA across all samples: red colour represents an expression level above mean, blue colour represents expression lower than the mean. Gray colour means that the specific mRNA has not been successfully detected with microarray. Numbers for clinicopathological features indicate the following: EOFUS (1 = no distant metastasis, 2 = distant metastasis), Tsize (Tumour size: 1≤2 cm, 2 >2 cm) and Nottgrade (Nottingham grade: 1 = grade 1, 2 = grade 2, 3 = grade 3), Histologic type (1 = Tubular, 2 = Colloid, 3 = Medullary, 4 = Lobular, 5 = Ductal, 6 = mix Ductal/Lobular, 7 = Others), MAI10 (1<10, 2≥10), PPH3_13 (0<13, 1≥13), HER2 (0 = 0 or 1+, 1 = 2+ or 3+), PR (1<1%, 2 = 1–9% positive tumour cells, 3≥10% positive tumour cells), ERα (1<1% positive tumour cells, 3≥1% positive tumour cells), TNP (0 = positive for either ERα/PR/Her2, 1 = negative for ERα and PR and HER2), and CK5/6 (0 = no staining, 1 = any percentage of positive tumour cells).