Topological organization of ABCA4 and conservation analysis.
- Yu Zhou (89766)
- Siyu Tao (535480)
- Hui Chen (28597)
- Lulin Huang (256539)
- Xiong Zhu (535481)
- Youping Li (111211)
- Zhili Wang (535482)
- He Lin (217878)
- Fang Hao (535483)
- Zhenglin Yang (24489)
- Liya Wang (161745)
- Xianjun Zhu (144118)
Publication date
March 2014
DOIAbstract
<p>(A) Protein alignment showed conservation of residues ABCA4 Y808X and G607R across nine species. These two mutations occured at an evolutionarily conserved amino acid. The ABCA4 mutation G607R occured in the NBD1 while Y808X occured in the disc lumen region between TMD1. (B) Topological organization of ABCA4 in the disc membrane was shown. The domain organization included exocytoplamic domain (ECD), nucleotide binding domain (NBD) and transmembrane domain (TMD).</p
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