Distribution of the identified GATA4 mutation and multiple sequence alignment of GATA4 protein.

<p>(A) Sequencing results of the GATA4 mutation. The arrow indicates the heterozygous nucleotides of C/T. (B) A schematic diagram of GATA4 shows the location of the p.R311W mutation. (C) Multiple sequence alignment of the GATA4 indicates that residue 311 is highly evolutionarily conserved in mammals.