Regulatory networks showing clusters of differentially-regulated genes predicted by mRNA microarray and validated by 96-well qPCR assay.

<p>The nodes represent the genes and the solid lines depict the interactions between two molecules. Red- and green-colored panels show significantly increased and decreased expression in the FD-fed mice compared to the SD-fed mice (log_1.5 (FD-/SD-fed mice). The right and left panels represent the mRNA microarray and qPCR output, respectively. The molecules without color are not mined by the present analysis; they are used to build the networks. These molecules constitute the major hubs of this network, but are not identified in the data shown here.