A comparison of breakpoints identified in our study with breakpoints found in other studies of <i>S. pastorianus</i>.

<p>We noted the presence of absence of similar breakpoints found in <i>S. pastorianus</i> strains analysed in four previous studies, Bond <i>et al</i>. 2004 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092203#pone.0092203-Bond1" target="_blank">[15]</a>, Dunn and Sherlock 2008 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092203#pone.0092203-Dunn1" target="_blank">[10]</a>, James <i>et al</i>. 2008 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092203#pone.0092203-James1" target="_blank">[21]</a> and Nakao <i>et al</i>. 2009 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092203#pone.0092203-Nakao1" target="_blank">[13]</a>. Grey shading indicates the presence of a breakpoint found within the same gene or a nearby/adjacent gene. *Breakpoints in both DBVPG 6033 and DBVPG 6261 fall within UTP4, but in differing locations. **The strains analysed in the study by James <i>et al</i>. 2008 are the product of mutagenesis and a laboratory evolution experiment. Cells labelled “cluster” within the Dunn and Sherlock (2008) analysis refer to breakpoints identified in our study which were not explicitly identified by the aforementioned study, but that fall within breakpoint cluster regions determined by the author across 17 strains of <i>S. pastorianus</i>.