X-ray irradiation delays LL/C tumor growth and antibody-mediated immunomodulation increases TGD in C57BL/6 mice.

<p>(A) Growth curves of LL/C tumors in non-irradiated (solid line, n = 5/each group) and irradiated (dashed line, n = 5/each group) groups. Effects of the anti-CTLA-4 (closed triangles), anti-FR4 (open squares), anti-GITR (open diamonds) immunomodulatory antibodies, and the saline control (for the non-treated group, closed circles) were examined. X-ray irradiation was performed when tumors reached 100 mm³ in volume (Day 0); bars, SD. (B) Survival curves for each group of LL/C-inoculated C57BL/6 mice; non-treated (thin solid line), irradiated (thick solid line), anti-CTLA-4 antibody-treated (thin dotted line), irradiation plus anti-CTLA-4 antibody-treated (thick dotted line), anti-FR4 antibody-treated (thick dashed line), irradiation plus anti-FR4 antibody-treated (thin dashed line), anti-GITR antibody-treated (thick dash-dotted line), and irradiation plus anti-GITR antibody-treated (thin dash-dotted line).