Action potential (AP) and Ca²⁺ alternans induced by NKA inhibition.

<p>The cell was paced at 0.25(by 50%). AP and Ca²⁺ alternans were observed at the end of pacing. Black: control; Red: 50% NKA inhibition; Dark green: 50% NKA inhibition+90% mNCE inhibition. (A): mitochondrial membrane potential (ΔΨ_m); (B): ATP_i; (C): SERCA Ca²⁺ uptake; (D): [Ca²⁺]_SR; (E): [Ca²⁺]_i and (F): AP. In this simulation, <i>shunt</i> = 2.5% and p1:p2 = 1∶3.