AbstractCardiac alternans, a putative trigger event for cardiac reentry, is a beat-to-beat alternation in membrane potential and calcium transient. Alternans was originally attributed to instabilities in transmembrane ion channel dynamics (i.e., the voltage mechanism). As of this writing, the predominant view is that instabilities in subcellular calcium handling are the main underlying mechanism. That being said, because the voltage and calcium systems are bidirectionally coupled, theoretical studies have suggested that both mechanisms can contribute. To date, to our knowledge, no experimental evidence of such a dual role within the same cell has been reported. Here, a combined electrophysiological and calcium imaging approach was developed...
AbstractInstability in the intracellular Ca2+ handling system leading to Ca2+ alternans is hypothesi...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
<div><p>Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon wher...
AbstractCardiac alternans, a putative trigger event for cardiac reentry, is a beat-to-beat alternati...
AbstractBeat-to-beat alternation of the action potential duration (APD) in paced cardiac cells has b...
Abstract—Spatially discordant alternans, where the action potential duration (APD) and intracellular...
RATIONALE: Cardiac repolarization alternans is an arrhythmogenic rhythm disturbance, manifested in i...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
AbstractInstability in the intracellular Ca2+ handling system leading to Ca2+ alternans is hypothesi...
Ordinary differential equations allow us to model the behavior of single cardiac cells in response t...
T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action potenti...
T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action potenti...
Cardiac alternans is characterized by alternating weak and strong beats of the heart. This signaling...
AbstractInstability in the intracellular Ca2+ handling system leading to Ca2+ alternans is hypothesi...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
<div><p>Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon wher...
AbstractCardiac alternans, a putative trigger event for cardiac reentry, is a beat-to-beat alternati...
AbstractBeat-to-beat alternation of the action potential duration (APD) in paced cardiac cells has b...
Abstract—Spatially discordant alternans, where the action potential duration (APD) and intracellular...
RATIONALE: Cardiac repolarization alternans is an arrhythmogenic rhythm disturbance, manifested in i...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
AbstractInstability in the intracellular Ca2+ handling system leading to Ca2+ alternans is hypothesi...
Ordinary differential equations allow us to model the behavior of single cardiac cells in response t...
T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action potenti...
T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action potenti...
Cardiac alternans is characterized by alternating weak and strong beats of the heart. This signaling...
AbstractInstability in the intracellular Ca2+ handling system leading to Ca2+ alternans is hypothesi...
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where differ...
<div><p>Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon wher...