Celastrol inhibited LP-1 human multiple myeloma cell proliferation.

<p>Morphological signatures of celastrol growth inhibitory effects. Cells were treated with various doses of celastrol and cell viability was determined by MTT assay. Computer-assisted phase-contrast microscopy illustrations of control LP-1 human multiple myeloma cells (A) and treated with celastrol at concentration 0.78125 µM for 72 h (B). IC50 was shown as calculated by Prism 5.0. The IC50 growth inhibitory concentration for 72 h is 0.8817 µM (C).