Comparison of the shared amino acid 6-mer words with the greatest average sequence score among gram-positive free-living (Free) and pathogenic (Path) microbes.

<p>NOTE: The gram-positive FREE and PATH dictionaries used in the LDA analysis for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096910#pone-0096910-g004" target="_blank">Fig. 4</a> were merged into an “averaged” dictionary of 6-mer amino acid words that were present in both groups. The common 6-mer words with the largest difference (expressed as a ratio) in selection scores between FREE and PATH word distance were aligned against NCBI’s Conserved Domain Database to identify potential proteins in which these words appear.</p><p>(1) Conserved Domain Database: <a href="http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml" target="_blank">http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml</a>.</p><p>(2) Cross-referenced database entry within CDD.