<p>Mean normalised expression profile of individual clusters (y axis, ±SD, n = 4) at each time point (x axis; 0, 1, 3, 6, 12 and 24 hours) for each cluster. N: number of transcripts within cluster; P: most significant canonical pathway (IPA). Clusters are grouped by similarity in kinetic profile (Pearsons correlation, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0097702#pone.0097702.s007" target="_blank">Table S2</a>) and top canonical pathway.</p
<p> Red, increase in transcript abundance (up-regulation); green, decrease in transcript abundance (...
<p>K = 25 clusters. The <i>x</i> axis presents the sample collection time points: I = 9 weeks of ver...
a<p>Top Networks, BioFunctions, Canonical Pathways or Tox Lists from Ingenuity Pathway Analysis that...
<p>Consensus clustering indicates A) 8 clusters for transcript data with the priming dose and B) 5 c...
<p>Six clusters were generated based on comparison of point-wise similarity of genome-wide gene expr...
<p>Three clusters of transcripts were identified through <i>k</i>-means clustering (<a href="http://...
<p>A two–way clustering of normalized 454 sequence count data using Ward’s hierarchical cluster algo...
(A) Clusters one to three represent kinetics of up-regulated genes, (B) whereas clusters four to eig...
<p>The y-axis shows the reads count, on log2 scale, of each transcript. All clusters contain differe...
<p>Clusters were created from averaging data from two biological replicates. Full cluster data are s...
<p>(A) Pearson correlation and (B) Euclidean distance as distance measure. Each line represents a ge...
<p>mRNA and protein profiles, normalized to each molecule’s maximum value, were clustered by geometr...
<p>(A) Centroid plots with mean and standard deviation of the expression values [Ln(meancenteredFPKM...
<p>Each dot represents a transcript. In case of differential expressed transcripts (n = 2,162) the d...
<p>MetaCore Pathway analysis was conducted on the differential gene expression of Cluster-1 at 1 wee...
<p> Red, increase in transcript abundance (up-regulation); green, decrease in transcript abundance (...
<p>K = 25 clusters. The <i>x</i> axis presents the sample collection time points: I = 9 weeks of ver...
a<p>Top Networks, BioFunctions, Canonical Pathways or Tox Lists from Ingenuity Pathway Analysis that...
<p>Consensus clustering indicates A) 8 clusters for transcript data with the priming dose and B) 5 c...
<p>Six clusters were generated based on comparison of point-wise similarity of genome-wide gene expr...
<p>Three clusters of transcripts were identified through <i>k</i>-means clustering (<a href="http://...
<p>A two–way clustering of normalized 454 sequence count data using Ward’s hierarchical cluster algo...
(A) Clusters one to three represent kinetics of up-regulated genes, (B) whereas clusters four to eig...
<p>The y-axis shows the reads count, on log2 scale, of each transcript. All clusters contain differe...
<p>Clusters were created from averaging data from two biological replicates. Full cluster data are s...
<p>(A) Pearson correlation and (B) Euclidean distance as distance measure. Each line represents a ge...
<p>mRNA and protein profiles, normalized to each molecule’s maximum value, were clustered by geometr...
<p>(A) Centroid plots with mean and standard deviation of the expression values [Ln(meancenteredFPKM...
<p>Each dot represents a transcript. In case of differential expressed transcripts (n = 2,162) the d...
<p>MetaCore Pathway analysis was conducted on the differential gene expression of Cluster-1 at 1 wee...
<p> Red, increase in transcript abundance (up-regulation); green, decrease in transcript abundance (...
<p>K = 25 clusters. The <i>x</i> axis presents the sample collection time points: I = 9 weeks of ver...
a<p>Top Networks, BioFunctions, Canonical Pathways or Tox Lists from Ingenuity Pathway Analysis that...