Pathway analysis demonstrates a high degree of interaction among the transcripts of Cluster-1.

<p>MetaCore Pathway analysis was conducted on the differential gene expression of Cluster-1 at 1 week post-surgery. The data were imported into Cytoscape for visualization. Diamonds represent transcription factors and ovals represent all other proteins. Arrows represent the direction of the interaction. The intensity of red coloring is indicative of the magnitude of upregulation. Values ranged from 1.23 (lightest pink) to 19.2 (darkest red). Of the 88 genes in Cluster-1, 62 had known interactions. The significant level of interaction among the transcripts along with the <i>a priori</i> hypothesis for the existence of Cluster-1 suggests this is a stable, biologically relevant cluster.