Illustration of histological response evaluation using Mandard score.

<p>A) Tumour regression grade 2 (Mandard). Few, scattered residual cancer areas (arrows) separated by fibrosis (*). One tumour area is surrounding a vessel (V) and another tumour area is seen to the left. This patient was a histological responder. B) Tumour regression grade 4 (Mandard). Residual cancer areas (arrows) outgrowing fibrosis (*). This patient was a histological nonresponder.