γδ T cells reduce experimental gut injury.

<p>A) Representative H&E staining of distal small intestines isolated from dam fed wild-type (1) or TCRδ^−/− (3) mice with normal histologic appearance; or wild-type (2) or TCRδ^−/− (4) mice subjected to experimental gut injury (PAF/LPS) as described (scale marker = 100 µm). Note shortened villi and epithelial sloughing with inflammatory infiltrate in wild-type PAF/LPS mice (2) and submucosal edema with severe villous sloughing in TCRδ^−/− PAF/LPS mice (4). B) Histologic severity score (mean ±SE) of distal small intestinal sections obtained from dam fed wild-type (WT control) or TCRδ^−/− (tcrδ^−/− control) mice; or wild-type (WT PAF/LPS) or TCRδ^−/− (tcrδ^−/− PAF/LPS) mice subjected to experimental gut injury as described. Data are representative of 4 independent experiments with at least 3 mice per condition per experiment (*p<0.05).