MiR-92a directly regulates <i>Smad7</i> expression via 3′-UTR site.

<p>A. The potential binding site for miR-92a in the 3′-UTR of <i>Smad7</i> mRNA. The complementary nucleotides between miR-92a and the target region of <i>Smad7</i> 3′-UTR are indicated with short vertical lines. B. Luciferase reporter assay was performed by co-transfection of 293T cells with luciferase reporter containing the 3′-UTR of rat <i>Smad7</i> with miR-92a mimic. Luciferase activity was determined 24 h after transfection. Data are presented as mean±SEM from three independent experiments (*<i>P</i><0.05 <i>vs.</i> the control group).