Spinal trabecular analysis of PPS-treated MPS VI rats.

<p>3-D microCT reconstructions of (<b>A</b>) normal, (<b>B</b>) untreated MPS VI, (<b>C</b>) 1 mg/kg, (<b>D</b>) 2 mg/kg, and (<b>E</b>) 4 mg/kg sc treated T1 thoracic vertebrae. All images were taken at the point where the pedicle connected with the spinal body. As seen in the untreated MPS VI image (<b>B</b>), a significant amount of dense cortical tissue (indicated by a whiter color intensity) is present compared to the normal animal (<b>A</b>). The cortical tissue also appeared to grow into the trabecular area in MPS VI animals (indicated by arrows and arrowheads). The 2 and 4 mg/kg PPS doses reduced the cortical in-growth and promoted the formation of better-oriented trabeculae in the MPS VI rat vertebrae. P values to represent statistical differences are presented as * for p<0.05 and ** for p<0.01.