MicroCT images of femurs and vertebrae of PPS-treated and control rats.

<p>A) Representative reconstructed images from femurs showing mid-coronal and transverse growth plates (arrows). Note “detached” growth plates and condyles in MPS (white arrows) and non-responder animal (black arrows) which were improved in responder animals. B) Representative scaled 2D images from L2 vertebrae showing transverse, sagittal and coronal views. MPS vertebrae are shorter and wider than normal and are partially recovered with PPS treatment. Note that in the PPS-treated responder animal there were changes evident in the trabecular, but not in the cortical bone of both femurs and vertebrae.