MAPK Inhibitors and Vit. C inhibited the LPS-induced phosphorylation of p38 and ERK.

<p>Cells were treated for 180(control), LPS (100 ng/ml) alone, or LPS combined with 20 µM of the p38 inhibitor SB203580 or ERK inhibitor PD98059, or 10 mM of Vit. C, and then harvested to conduct western blot analyses of p-p38 (A) and p-ERK (p-p42/44) (B). The data are represented as the mean ± SEM based on 3–4 independent experiments. ** <i>p</i><.05, ** <i>p</i><.01, and *** <i>p</i><.001 versus Cont.; ⁺<i>p</i><.05, ⁺⁺<i>p</i><.01 and ⁺⁺⁺<i>p</i><.001 versus LPS alone.