Significantly mutated pathways.

<p><b>A,</b> Top 30 of 113 significantly mutated pathways and the difference in <b>B,</b> the percentage of known cancer genes or damaging genes and <b>C,</b> the conservative score between mutated genes in significantly mutated pathways (In SMP) and those not in significantly mutated pathways (Not In SMP). Coverage represents the fraction of tumors with at least one mutated gene in the specified pathway. Known cancer genes were obtained from the F-census database, and damaging genes were predicted using PolyPhen.