Pathway analysis.

<p>Graphical representation of the protein network retrieved using the Ingenuity Pathway Analysis Tool. Proteins are represented as nodes, the biological relationships between the nodes are represented as lines. Proteins identified by PCA and PLS-DA analysis and indicated as discriminant among controls, low-grade and high-grade tumors are in highlighted blue. Most proteins differentially expressed in gliomas are closely connected in the network through four major hubs: Huntingtin, HNF4α, 14-3-3ζ (YWHAZ) and c-Myc. Four external edges: differentially expressed proteins identified by MS (red) and direct interactors with the four major hubs (blue bridges and strengthened contours).