<p>Total number of rats used in toxicity studies at the Safety Assessment Research Unit (black line) and total number of reported regulatory toxicity studies, one month or longer (black bars) and shorter investigative toxicity/mechanistic studies (grey bars) during the years 2006–2010.</p
This reference list includes all cited references in the Peer Review Panel reports and key reference...
<p>CD: commercial diet, GM: genetically modified, WT: wild-type.</p><p>Summary of microscopic pathol...
The principles of the 3Rs, Replacement, Reduction and Refinement, are being increasingly incorporate...
<p>Actual number of animals used in 2009 (black bars) compared with the estimated number of animals ...
<p>Dosage groups for reproduction/developmental toxicity study in Wistar rats.</p
<p>Note: Numbers in the table represent number of animals per group for males and females. The first...
<p>Descriptive statistics of rats exposed to adolescent stress (PND 45–51) and controls.</p
<p>Corpora lutea and implantation sites in numbers in reproductive/ developmental toxicity study in ...
<p>Number of animals used per treatment group in the efficacy and safety experiments.</p
1024. Extensive animal studies are carried out during the development of new medicines to assess tox...
The studies reported herein were, with one exception, all done in the same laboratory. They were int...
Statistical hypothesis tests are used as a flagging device to highlight diferences worth further att...
<p>Male Sprague-Dawley rats (N = 4/group) received once daily for 14 days administration of 90 mg/kg...
Cleared for public release; distribution unlimited. This and other AFRRI publications are available ...
Chronic 6- and 12-month rat toxicology studies were evaluated for their ability to predict tumor out...
This reference list includes all cited references in the Peer Review Panel reports and key reference...
<p>CD: commercial diet, GM: genetically modified, WT: wild-type.</p><p>Summary of microscopic pathol...
The principles of the 3Rs, Replacement, Reduction and Refinement, are being increasingly incorporate...
<p>Actual number of animals used in 2009 (black bars) compared with the estimated number of animals ...
<p>Dosage groups for reproduction/developmental toxicity study in Wistar rats.</p
<p>Note: Numbers in the table represent number of animals per group for males and females. The first...
<p>Descriptive statistics of rats exposed to adolescent stress (PND 45–51) and controls.</p
<p>Corpora lutea and implantation sites in numbers in reproductive/ developmental toxicity study in ...
<p>Number of animals used per treatment group in the efficacy and safety experiments.</p
1024. Extensive animal studies are carried out during the development of new medicines to assess tox...
The studies reported herein were, with one exception, all done in the same laboratory. They were int...
Statistical hypothesis tests are used as a flagging device to highlight diferences worth further att...
<p>Male Sprague-Dawley rats (N = 4/group) received once daily for 14 days administration of 90 mg/kg...
Cleared for public release; distribution unlimited. This and other AFRRI publications are available ...
Chronic 6- and 12-month rat toxicology studies were evaluated for their ability to predict tumor out...
This reference list includes all cited references in the Peer Review Panel reports and key reference...
<p>CD: commercial diet, GM: genetically modified, WT: wild-type.</p><p>Summary of microscopic pathol...
The principles of the 3Rs, Replacement, Reduction and Refinement, are being increasingly incorporate...